Juvenile nasopharyngeal angiofibroma is a rare, highly luiz a cr, romualdo s lt, fava a s. We analyzed 20 patients with nasopharyngeal angiofibroma who underwent surgery in the otolaryngology service between 2004 and 2011. Vessels are thinwalled, lack elastic fibers, have absent or incomplete smooth muscle, and vary in appearance from stellate or staghorn to barely conspicuous because of stromal compression. Nasopharyngeal angiofibroma symptoms aurora health care. Multiport combined endoscopic approach to nonembolized. Angiofibromas are benign, vascular tumors that most often occur in young, adolescent males on the head and neck. Cheol soo seo, moon hee han, kee hyun chang, and kyung mo yeon. This is a classical presentation of juvenile nasopharyngeal angiofibroma. The activity of this drug is further evidence for a hormonal cause for the condition. Its incidence practically aims to him at being exclusive of men in ages next to the puberty. To desmostrate that the endoscopic surgery is possible and succeful in most of the case without embolization n method. Presenting symptoms were epistaxis and nasal blockage while two patients also had dacryocystitis and secretory otitis media. Nasopharyngeal angiofibroma na is a rare, vascular tumor affecting adolescent males.
Dermal dendritic cells usually stain for factor xiiia. Juvenile nasopharyngeal angiofibroma jna is a rare vascular tumour, accounts for 0. Angiofibromas have been sporadically described in extanasopharyngeal locations. Juvenile nasopharyngeal angiofibroma radiology reference. The first description of this tumour dates from nucci et al. Given its vascularity, prominent flow voids are seen on mri leading to a salt and pepper appearance. Call 4166330001 or email us today to find out the best angiofibroma treatment option for you.
Nov 04, 2014 nasopharyngeal juvenile angiofibroma resected endoscopically. Nasopharyngeal angiofibroma is a histologically benign tumor composed of stroma and vessels. The vascular component of the lesion is prone to bleeding and responsible for its clinical malignancy. These lesions include fibrous papule, facial angiofibroma, pearly penile papule, adenoma sebaceum, periungual fibroma, and koenens tumor. Juvenile nasopharyngeal angiofibroma radiology case. Originating in the margin of the sphenopalatine foramen, it extends itself to the pterygopalatine fosse, paranasal sinus and nasal cavity, leading to symptoms. In tumors with extension to parapharyngeal space, the endonasal approach was observed to be inadequate. Although the use of nonsurgical therapies is described in the literature, surgery is currently considered the ideal treatment for. Angiofibroma confined to the pterygoid muscle region. The patient in this photo has several facial angiofibromas. Review article nasopharyngeal angiofibroma ashutosh hota s.
Angiofibroma is a descriptive term for a group of lesions with different clinical presentations but with the same histopathology. Surgical approaches to the parapharyngeal space pps are challenging by virtue of deep location and neurovascular content. A juvenile nasopharyngeal angiofibroma jna is a noncancerous tumor made up of blood vessels that grow at the posterior aspect of the nose. Angiofibroma medical definition merriamwebster medical. Nasopharyngeal angiofibroma introduction juvenile nasopharyngeal angiofibroma jna is a benign, but locally aggressive and extremely vascular head and neck neoplasm, occurring almost exclusively in the nasopharynx of adolescent males. Juvenile nasopharyngeal angiofibroma is a rare benign vascular tumor of the nasopharynx. Paranasal juvenile angiofibroma jama otolaryngologyhead. Staging of juvenile nasopharyngeal angiofibromas is performed with crosssectional imaging and relies on the identification of local tumor extent, and invasion of adjacent spaces. The juvenile nasopharyngeal angiofibroma is a benign slowgrowing tumor with vascular component which affects males in their early puberty and adolescence, and in very few cases men over 25 years.
There are three main types of treatment for juvenile nasopharyngeal angiofibroma. Hemangiofibroma definition of hemangiofibroma by medical. Inourcase,ct,angiography,andmr show a very unusually located angiofibroma. Answers from specialists on treatments for angiofibroma. Juvenile nasopharyngeal angiofibroma extending into the oral. Nasopharyngeal angiofibroma is a histologically benign but locally aggressive vascular tumor of the nasopharynx that arises from the superior margin of the sphenopalatine foramen and grows in the back of the nasal cavity. Definition of angiofibroma nci dictionary of cancer terms. Juvenile nasopharyngeal angiofibroma has been documented since the time of hippocrates 4 bc. Tratamiento quirurgico del angiofibroma juvenil unido a cinco. It is the most common benign tumor of the nasopharnyx but only accounts for less than 0. To add to an existing tiff or pdf file, scan or import the documents to be added, highlight the documents, and go to scanmerge files. Picture of angiofibroma facial angiofibromas are benign, vascular tumors that most often occur in young, adolescent males on the head and neck.
Combine pdfs in the order you want with the easiest pdf merger available. Jul 15, 2015 juvenile nasopharyngeal angiofibroma jna is a benign neoplasm of the nasopharynx. It most commonly affects adolescent males and may grow into fissures of the. Generally, an angiofibroma presents as 1 to 5 mm skincolored to erythematous domeshape papule on the face. Do not attempt selfremoval of angiofibromas as that can often lead to permanent scars.
Stanford medicine school of medicine departments surgical pathology criteria cellular angiofibroma navigation for this section. Angiofibromas are small, reddish brown or even fleshcolored, smooth, shiny, 0. Juvenile angiofibroma is a rare benign lesion originating from the pterygopalatine fossa with distinctive epidemiologic features and growth patterns. Due to aggressive local growth, skull base location and risk of profound hemorrhage, na is a challenge for surgeons.
Juvenile nasopharyngeal angiofibroma jna is a rare tumor that exhibits a predictable spreading pattern. Variables analyzed included patient age, sex, symptoms, tumor stage, treatment, duration of surgery, volume of intraoperative bleeding, need for nasal packing after surgery, length of hospitalization, immediate and late complications, recurrence, and. A read is counted each time someone views a publication summary such as the title, abstract, and list of authors, clicks on a figure, or views or downloads the fulltext. They often grow quickly during puberty, then slow down or stop growing entirely after adolescence. Juvenile nasopharyngeal angiofibroma jna is a rare benign tumor arising predominantly in the.
Infact hippocrates goes on to describe a polyp in the nose which weeped blood. May 16, 2018 juvenile nasopharyngeal angiofibroma jna occurs exclusively in males. Adolescents and young adults between 14 and 25 years are affected, and there is a distinct male predominance. Juvenile nasopharyngeal angiofibroma is described as a rare and benign disease, which is mainly diagnosed in male adolescents. Juvenile nasopharyngeal angiofibroma jna is a benign, lo5. Juvenile nasopharyngeal angiofibroma jna is a benign tumor that tends to bleed and occurs in the nasopharynx of prepubertal and adolescent males. We offer a widget that you can add to your website to let users look up cancerrelated terms. Angiofibroma definition of angiofibroma by medical dictionary. Acessos cirurgicos no angiofibroma nasofaringeo juvenil relato. It originates in the posteriorlateral wall of the nasopharynx, where the sphenoid process of palatine bone meets the horizontal lamina of vomer and part of. The patient in this photo also has tuberous sclerosis.
Females with juvenile nasopharyngeal angiofibroma jna should undergo genetic testing. Nasopharyngeal juvenile angiofibroma resected endoscopically. Sclerosing naevus these usually do not exhibit vascular ectasia. Pdf the management of juvenile nasopharyngeal angiofibroma jna has changed during the.
Differential diagnosis cellular angiofibroma surgical. Abstract juvenile angiofibroma is a benign fibroangiomatous tumor of relatively rare occurrence, developing most frequently in male adolescents. Juvenile nasopharyngeal angiofibroma jna is a rare tumor that predominantly occurs in adolescent males, the average age of occurence being 15. Juvenile nasopharyngeal angiofibroma jna is a rare benign tumor arising predominantly in the nasopharynx of adolescent males. Angiofibroma, juvenile fibroma, angiofibroma or nasopharyngeal hemangioma, it. Although the treatment of choice is surgery, there is no consensus on what is the best approach. In 1906 chareau revived the interest in the study of juvenile nasopharyngeal angiofibroma. The first soft tissue tumour with a relatively pelvic sitespecificity was a benign stromal polyp described in the early 1960. The typical patient is an adolescent male with a clinical history of recurrent epistaxis and nasal obstruction. Juvenile nasopharyngeal angiofibroma jna is a formidable hypervascular tumor that involves multiple compartments with increase in size. Follow these steps to quickly combine and arrange documents.
It shows very aggressive behavior due to local invasiveness and is associated with various symptoms. Jul 19, 2015 cellular angiofibroma ca represents a quite recently described mesenchymal tumour that occurs in both genders, in particular in the vulvovaginal region in women and in the inguinoscrotal area in men. Looking for online definition of hemangiofibroma in the medical dictionary. Juvenile nasopharyngeal angiofibroma jna is a rare vascular tumour which is benign but. The juvenile nasopharyngeal angiofibroma is a rare benign tumor composed of connective fibrous tissue and abundant vascular spaces covered with endothelium.
Juvenile nasopharyngeal angiofibromas occur almost exclusively in males and usually in adolescence 15 years. Imaging and management of angiofibroma springerlink. Ppt juvenile nasopharyngeal angiofibroma powerpoint. Asymptomatic, red to skin colored, dome shaped, firm papule usually on the nose or central face. Histologically, angiofibromas are characterized by fibrosis of the dermis and blood vessels. A male, 21 years of age, without relevant history, presented with left exophthalmos and diplopia in extreme gaze positions with 2 weeks evolution, without clinic of epistaxis or nasal obstruction. Hormone therapy involves the use of a drug called flutamide, which acts by blocking testosterone receptors. Their use is purely for academic and teaching purposes. Licensed to youtube by the orchard music on behalf of apollo music. Juvenile nasopharyngeal angiofibroma is a rare, highly vascular, and histologically benign tumor, generally observed in male adolescents. The tumor contains many blood vessels and spreads within the area in which it. Surgical approaches to juvenile nasopharyngeal angiofibroma. Angiofibroma nasofaringeo juvenil y angioma juvenil.
The possibility of juvenile nasopharyngeal angiofibroma originating in areas other than the vault of the nasopharynx has long been recognized in the european literature, 1 but the english literature scarcely mentions extranasopharyngeal origin. Juvenile nasopharyngeal angiofibroma a free powerpoint ppt presentation displayed as a flash slide show on id. Cellular angiofibroma ca belongs to soft tissue tumours that predominantly occur in the distal genital tract of both genders. Review article nasopharyngeal angiofibroma ashutosh hota. Angiofibroma is a pink, firm, 1 to 2mm domeshaped papule most commonly located over the nasal bridge and cheeks fig.
The contents of this presentation do not have any intended commercial use. This is a histologically benign lesion with very aggressive local behavior. Generally, an angiofibroma presents as 1 to 5 mm skincolored to erythematous. The nci dictionary of cancer terms features 8,550 terms related to cancer and medicine. Learn how to combine files into a single pdf file using adobe acrobat dc. Additional interphase fish using a breakapart probe for the ncoa2 gene in the six fusionnegative cases did not reveal any split signals. Juvenile nasopharyngeal angiofibroma jna is rare in patients older than 25 years. The most common presenting symptom is painless nasal obstruction or epistaxis. It is a highly vascularized slow growing tumor, but locally invasive and destructive. Hippocrates described the tumor in the 5th century bc, but friedberg first used the term angiofibroma in 1940.
Hence the name juvenile nasopharyngeal angiofibroma. Interphase fish on cut sections from nine additional cases of soft tissue angiofibroma using pools of bacs covering ahrr and ncoa2 yielded fusion signals in at least 10% of the nuclei in three cases. These tumors are highly aggressive and are associated with significant morbidity and mortality due to its tendency to bleed. S100 stain will highlight the melanocytes, and will be negative in fibrous papules. The juvenile nasopharyngeal angiofibroma jna is a benign tumoral disease that may have a very aggressive. Our pdf merger allows you to quickly combine multiple pdf files into one single pdf document, in just a few clicks. Juvenile nasopharyngeal angiofibroma extending into the. Juvenile nasopharyngeal angiofibromas are a rare benign, but locally aggressive, vascular tumors that occur almost exclusively in young men on imaging, they present as a vividly enhancing softtissue masses centered on the sphenopalatine foramen. Nasal obstruction may become total, with adenoidtype speech.
Nasopharyngeal angiofibroma is usually encapsulated and composed of vascular tissue and fibrous stroma with coarse or fine collagen fibers. The incidence of juvenile angiofibroma is less than 0. For a discussion of this entity please refer to the parent article. Toronto dermatology centre is located in toronto, ontario, and serves men and women in north york, vaughan, richmond hill, york, aurora. Angioma nasofaringeo juvenil, fibroma vascular, hemangiofibroma nasofaringeo juvenil, fibroangioma juvenil y fibroma juvenil. The pictures used in this presentation have been obtained from a number of sources. It is almost exclusicely encountered in adolescent males 1. Nonsurgical treatments are available, including the use of hormones estrogen, testosterone, radiation therapy, chemotherapy, and recently, embolization. Angiofibroma is a fibrous and vascular tumour that commonly occurs in adolescent males and involves the nasopharynx. It most commonly affects adolescent males because it is a hormonesensitive tumor. May 16, 2018 nasopharyngeal angiofibroma is usually encapsulated and composed of vascular tissue and fibrous stroma with coarse or fine collagen fibers.
Visual acuity was 2020 in both eyes and intraocular pressure iop 24 mmhg in left eye le without limitations in ocular movement. Radiologists prior knowledge on the tumors characteristics aids in establishing a diagnosis. Case report endoscopic excision of juvenile nasopharyngeal. It is an aggressive neoplasm and shows a propensity for destructive local spread often extending to the base of the skull and into the cranium. Juvenile nasopharyngeal angiofibromas jna are a rare benign, but locally aggressive, vascular tumor. The nose and nasopharynx were involved in four cases and the nose and right maxillary sinus in one. Cummings bj, blend r, keane t, fitzpatrick p, beale f et al. It has local characteristics of aggressiveness and expansion. Juvenile nasopharyngeal angiofibroma jna is a rare, benign, and highly vascular and locally aggressive tumor that accounts for 0. Pictures of skin diseases and problems angiofibroma. All patients had ct scans done and magnetic resonance imaging was required for two patients.
The tumors are fleshcolored to reddish and approximately 1 to 5 millimeters in diameter. Angiofibroma removal in toronto dermatology centre is a commonly performed procedure with great results. Juvenile nasopharyngeal angiofibromas are a rare benign, but locally aggressive, vascular tumors that occur almost exclusively in young men. Other names have been used as a nasopharyngeal fibroma, fibroma of the adolescent and bleeding fibroangioma 1.
1307 1505 650 661 763 83 117 166 814 618 414 293 634 1165 81 1203 926 1476 552 1418 117 887 353 1071 1366 1353 711 509 1189 903 1044 424 557 784 270 1287 350 653 496 1200 745 205 6 870 441 3 1458